Claudin 14 (CLDN14) Rabbit Polyclonal Antibody

CAT#: TA308473

Rabbit polyclonal antibody to claudin 14 (claudin 14)

Product Images

Sample (30 ug of whole cell lysate). A: Hela. B: Hep G2. 12% SDS PAGE. TA308473 diluted at 1:1000.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB:1:500-1:3000
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a region within amino acids 177 and 239 of Claudin 14 (Uniprot ID#O95500)
• Formulation: 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
• Concentration: lot specific
• Purification: Purified by antigen-affinity chromatography.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 26 kDa
• Gene Name: claudin 14
• Database Link:
  NP_652763
  Entrez Gene 56173 MouseEntrez Gene 304073 RatEntrez Gene 23562 Human
  UniProt ID O95500
• Background: Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. The encoded protein also binds specifically to the WW domain of Yes-associated protein. Defects in this gene are the cause of an autosomal recessive form of nonsyndromic sensorineural deafness. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq]
• Synonyms: DFNB29
• Note: Seq homology of immunogen across species: Mouse (92%), Rat (92%), Pig (85%), Rhesus Monkey (100%)

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Cell adhesion molecules (CAMs), Leukocyte transendothelial migration, Tight junction