HSD11B1 Rabbit Polyclonal Antibody

CAT#: TA308504

Rabbit polyclonal antibody to HSD11B1 (hydroxysteroid (11-beta) dehydrogenase 1)

Product Images

Sample (30 ug of whole cell lysate). A: Hep G2. 12% SDS PAGE. TA308504 diluted at 1:1000.

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  HSD11B1 antibody detects HSD11B1 protein at cytosol on hepatoma by immunohistochemical analysis. Sample: Paraffin-embedded hepatoma. HSD11B1 antibody (TA308504) dilution: 1:500.

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  Immunofluorescence analysis of paraformaldehyde-fixed HeLa, using HSD11B1 (TA308504) antibody at 1:200 dilution.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: ICC/IF:1:100-1:1000; IHC:1:100-1:1000; WB:1:500-1:3000
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a region within amino acids 232 and 292 of HSD11B1
• Formulation: 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
• Concentration: lot specific
• Purification: Purified by antigen-affinity chromatography.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 32 kDa
• Gene Name: hydroxysteroid (11-beta) dehydrogenase 1
• Database Link:
  NP_861420
  Entrez Gene 3290 Human
  UniProt ID P28845
• Background: The protein encoded by this gene is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq]
• Synonyms: 11-beta-HSD1; 11-DH; CORTRD2; HDL; HSD11; HSD11B; HSD11L; SDR26C1

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Androgen and estrogen metabolism, C21-Steroid hormone metabolism, Metabolic pathways