KLC1 Rabbit Polyclonal Antibody

CAT#: TA308531

Rabbit polyclonal antibody to KLC1 (kinesin light chain 1)

Product Images

Sample (30 ug of whole cell lysate). A: A549. 7.5% SDS PAGE. TA308531 diluted at 1:1000.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB:1:500-1:3000
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant fragment corresponding to a region within amino acids 114 and 441 of KLC1 (Uniprot ID#Q07866)
• Formulation: 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
• Concentration: lot specific
• Purification: Purified by antigen-affinity chromatography.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 64 kDa
• Gene Name: kinesin light chain 1
• Database Link:
  NP_891553
  Entrez Gene 16593 MouseEntrez Gene 171041 RatEntrez Gene 3831 Human
  UniProt ID Q07866
• Background: Conventional kinesin is a tetrameric molecule composed of two heavy chains and two light chains, and transports various cargos along microtubules toward their plus ends. The heavy chains provide the motor activity, while the light chains bind to various cargos. This gene encodes a member of the kinesin light chain family. It associates with kinesin heavy chain through an N-terminal domain, and six tetratricopeptide repeat (TPR) motifs are thought to be involved in binding of cargos such as vesicles, mitochondria, and the Golgi complex. Thus, kinesin light chains function as adapter molecules and not motors per se. Although previously named "kinesin 2", this gene is not a member of the kinesin-2 / kinesin heavy chain subfamily of kinesin motor proteins. Extensive alternative splicing produces isoforms with different C-termini that are proposed to bind to different cargos; however, the full-length nature and/or biological validity of most of these variants have not been determined. [provided by RefSeq]
• Synonyms: KLC; KNS2; KNS2A
• Note: Seq homology of immunogen across species: Mouse (97%), Rat (98%), Bovine (99%)

Reference Data

• Protein Families: Druggable Genome