IL1 Receptor II (IL1R2) Rabbit Polyclonal Antibody

CAT#: TA308544

Rabbit Polyclonal antibody to IL1 receptor 2 (interleukin 1 receptor, type II)

Product Images

Sample (30 ug of whole cell lysate). A: 293T. 10% SDS PAGE. TA308544 diluted at 1:1000

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  Immunohistochemical analysis of paraffin-embedded SW480 xenograft, using IL1R2 (TA308544) antibody at 1:100 dilution.

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  Immunofluorescence analysis of methanol-fixed A549, using IL1 Receptor 2 (TA308544) antibody at 1:500 dilution.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: ICC/IF:1:100-1:1000; IHC:1:100-1:1000; WB:1:500-1:3000
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant fragment corresponding to a region within amino acids 172 and 398 of IL1 Receptor 2 (Uniprot ID#P27930)
• Formulation: 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
• Concentration: lot specific
• Purification: Purified by antigen-affinity chromatography.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 45 kDa
• Gene Name: interleukin 1 receptor type 2
• Database Link:
  NP_775465
  Entrez Gene 711638 MonkeyEntrez Gene 7850 Human
  UniProt ID P27930
• Background: The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12. Two alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq]
• Synonyms: CD121b; IL1RB; MGC47725
• Note: Seq homology of immunogen across species: Monkey (94%)

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, MAPK signaling pathway