NSMAF Rabbit Polyclonal Antibody

CAT#: TA308550

Rabbit polyclonal antibody to FAN (neutral sphingomyelinase (N-SMase) activation associated factor)

Product Images

Western Blot analysis of NSMAF expression in transfected 293T cell line by NSMAF polyclonal antibody. A: Non-transfected lysate. B: NSMAF transfected lysate. 7.5% SDS PAGE. TA308550 diluted at 1:500

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  Immunohistochemical analysis of paraffin-embedded T (gastric CA), using NSMAF (TA308550) antibody at 1:100 dilution.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: IHC:1:100-1:1000; WB:1:500-1:3000
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant fragment corresponding to a region within amino acids 262 and 570 of FAN (Uniprot ID#Q92636)
• Formulation: 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
• Concentration: lot specific
• Purification: Purified by antigen-affinity chromatography.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 104 kDa
• Gene Name: neutral sphingomyelinase activation associated factor
• Database Link:
  NP_001138244
  Entrez Gene 18201 MouseEntrez Gene 353233 RatEntrez Gene 8439 Human
  UniProt ID Q92636
• Background: This gene encodes a WD-repeat protein that binds the cytoplasmic sphingomyelinase activation domain of the 55kD tumor necrosis factor receptor. This protein is required for TNF-mediated activation of neutral sphingomyelinase and may play a role in regulating TNF-induced cellular responses such as inflammation. Alternative splicing results in multiple transcript variants.
• Synonyms: FAN; GRAMD5
• Note: Seq homology of immunogen across species: Mouse (93%), Rat (91%)

Reference Data

• Protein Families: Druggable Genome