PRAK (MAPKAPK5) Rabbit Polyclonal Antibody
CAT#: TA308640
Rabbit polyclonal antibody to PRAK (mitogen-activated protein kinase-activated protein kinase 5)
Other products for "MAPKAPK5"
Specifications
Product Data | |
Applications | IF, WB |
Recommended Dilution | ICC/IF:1:100-1:1000; WB:1:500-1:3000 |
Reactivities | Human |
Host | Rabbit |
Isotype | IgG |
Clonality | Polyclonal |
Immunogen | Recombinant fragment contain a sequence corresponding to a region within amino acids 197 and 457 of PRAK (Uniprot ID#Q8IW41) |
Formulation | 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative. |
Concentration | lot specific |
Purification | Purified by antigen-affinity chromatography. |
Conjugation | Unconjugated |
Storage | Store at -20°C as received. |
Stability | Stable for 12 months from date of receipt. |
Predicted Protein Size | 54 kDa |
Gene Name | mitogen-activated protein kinase-activated protein kinase 5 |
Database Link | |
Background | The protein encoded by this gene is a member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. In vitro, this kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq] |
Synonyms | MAPKAP-K5; MK-5; MK5; PRAK |
Note | Seq homology of immunogen across species: Mouse (96%), Chicken (95%), Pig (97%), Rat (96%), Xenopus tropicalis (90%) |
Reference Data | |
Protein Families | Druggable Genome, Protein Kinase |
Protein Pathways | MAPK signaling pathway |
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