IL24 Rabbit Polyclonal Antibody

CAT#: TA308643

Rabbit polyclonal antibody to Interleukin-24 (interleukin 24)

Product Images

Sample (30 ug of whole cell lysate). A: A431. 12% SDS PAGE. TA308643 diluted at 1:1000.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB:1:500-1:3000
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a region within amino acids 142 and 206 of IL24 (Uniprot ID#Q13007)
• Formulation: 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
• Concentration: lot specific
• Purification: Purified by antigen-affinity chromatography.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 24 kDa
• Gene Name: interleukin 24
• Database Link:
  NP_851936
  Entrez Gene 93672 MouseEntrez Gene 170819 RatEntrez Gene 11009 Human
  UniProt ID Q13007
• Background: This gene encodes a member of the IL10 family of cytokines. It was identified as a gene induced during terminal differentiation in melanoma cells. The protein encoded by this gene can induce apoptosis selectively in various cancer cells. Overexpression of this gene leads to elevated expression of several GADD family genes, which correlates with the induction of apoptosis. The phosphorylation of mitogen-activated protein kinase 14 (MAPK7/P38), and heat shock 27kDa protein 1 (HSPB2/HSP27) are found to be induced by this gene in melanoma cells, but not in normal immortal melanocytes. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq]
• Synonyms: C49A; FISP; IL-24; IL10B; mda-7; MDA7; Mob-5; ST16
• Note: Seq homology of immunogen across species: Mouse (93%), Rat (80%)

Reference Data

• Protein Families: Druggable Genome, Secreted Protein
• Protein Pathways: Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway