SEC61A (SEC61A1) Rabbit Polyclonal Antibody

CAT#: TA308684

Rabbit Polyclonal antibody to SEC61A1 (Sec61 alpha 1 subunit (S. cerevisiae))

Product Images

Sample (30 ug of whole cell lysate). A: K562. 10% SDS PAGE. TA308684 diluted at 1:1000.

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  Immunohistochemical analysis of paraffin-embedded Cal27 xenograft, using SEC61A1 (TA308684) antibody at 1:500 dilution.

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  Immunofluorescence analysis of methanol-fixed A431, using SEC61A1 (TA308684) antibody at 1:200 dilution.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: ICC/IF:1:100-1:1000; IHC:1:100-1:1000; WB:1:500-1:3000
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a region within amino acids 413 and 476 of SEC61A1
• Formulation: 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
• Concentration: lot specific
• Purification: Purified by antigen-affinity chromatography.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 52 kDa
• Gene Name: Sec61 translocon alpha 1 subunit
• Database Link:
  NP_037468
  Entrez Gene 53421 MouseEntrez Gene 80843 RatEntrez Gene 404006 DogEntrez Gene 29927 Human
  UniProt ID P61619
• Background: The protein encoded by this gene belongs to the SECY/SEC61- alpha family. It appears to play a crucial role in the insertion of secretory and membrane polypeptides into the endoplasmic reticulum. This protein found to be tightly associated with membrane-bound ribosomes, either directly or through adaptor proteins. This gene encodes an alpha subunit of the heteromeric SEC61 complex, which also contains beta and gamma subunits. [provided by RefSeq]
• Synonyms: HSEC61; SEC61; SEC61A
• Note: Seq homology of immunogen across species: Mouse (100%), Rat (100%), Zebrafish (100%), Xenopus laevis (93%), Xenopus Tropicalis (100%), Dog (100%), Pig (100%), Rhesus Monkey (100%), Bovine (100%)

Reference Data

• Protein Families: Transmembrane
• Protein Pathways: Vibrio cholerae infection