TYK2 Rabbit Polyclonal Antibody

CAT#: TA308735

Rabbit polyclonal antibody to TYK2 (tyrosine kinase 2)


USD 415.00

5 Days*

Size
    • 100 ul

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Specifications

Product Data
Applications IF, WB
Recommended Dilution ICC/IF:1:100-1:1000; WB:1:500-1:3000
Reactivities Human
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen Recombinant fragment corresponding to a region within amino acids 680 and 1187 of TYK2 (Uniprot ID#P29597)
Formulation 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Concentration lot specific
Purification Purified by antigen-affinity chromatography.
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Predicted Protein Size 134 kDa
Gene Name tyrosine kinase 2
Background This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq]
Synonyms IMD35; JTK1
Note Seq homology of immunogen across species: Mouse (88%), Pig (88%), Bovine (87%)
Reference Data
Protein Families Druggable Genome, Protein Kinase
Protein Pathways Jak-STAT signaling pathway

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.