TRIM21 Rabbit Polyclonal Antibody

CAT#: TA308743

Rabbit Polyclonal antibody to SSA1 (tripartite motif-containing 21)

Product Images

Sample (30 ug of whole cell lysate). A: Molt-4. 10% SDS PAGE. TA308743 diluted at 1:1000.

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  Immunohistochemical analysis of paraffin-embedded DLD-1 xenograft, using SSA1 (TA308743) antibody at 1:500 dilution.

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  Immunofluorescence analysis of paraformaldehyde-fixed A431, using SSA1 (TA308743) antibody at 1:200 dilution.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: ICC/IF:1:100-1:1000; IHC:1:100-1:1000; WB:1:500-1:3000
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant fragment corresponding to a region within amino acids 254 and 475 of SSA1 (Uniprot ID#P19474)
• Formulation: 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
• Purification: Purified by antigen-affinity chromatography.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 54 kDa
• Gene Name: tripartite motif containing 21
• Database Link:
  NP_003132
  Entrez Gene 6737 Human
  UniProt ID P19474
• Background: This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The encoded protein is part of the RoSSA ribonucleoprotein, which includes a single polypeptide and one of four small RNA molecules. The RoSSA particle localizes to both the cytoplasm and the nucleus. RoSSA interacts with autoantigens in patients with Sjogren syndrome and systemic lupus erythematosus. Alternatively spliced transcript variants for this gene have been described but the full-length nature of only one has been determined. [provided by RefSeq]
• Synonyms: RNF81; Ro; RO52; SSA; SSA1
• Note: Seq homology of immunogen across species: Pig (81%), Bovine (82%)

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Systemic lupus erythematosus