Fatty Acid Synthase (FASN) Rabbit Polyclonal Antibody

CAT#: TA308751

Rabbit Polyclonal antibody to Fatty Acid Synthase (fatty acid synthase)

Product Images

Sample (50 ug of whole cell lysate). A: mouse liver. 5% SDS PAGE. TA308751 diluted at 1:1000.

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  Sample (30 ug of whole cell lysate). A: Molt-4. 5% SDS PAGE. TA308751 diluted at 1:1000

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  Immunohistochemical analysis of paraffin-embedded OECM1 xenograft, using Fatty Acid Synthase (TA308751) antibody at 1:500 dilution.

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  Fatty Acid Synthase antibody [N1N2], N-term detects Fatty Acid Synthase protein at cytoplasm by immunofluorescent analysis. Sample: 293T cells were fixed in 4% paraformaldehyde at RT for 15 min. Green: Fatty Acid Synthase protein stained by Fatty Acid Syn

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  Confocal immunofluorescence analysis (Olympus FV10i) of paraformaldehyde-fixed HeLa, using Fatty Acid Synthase (TA308751) antibody (Green) at 1:500 dilution. Alpha-tubulin filaments were labeled with anti-alpha tubulin antibody (Red) at 1:2000.

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Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: ICC/IF:1:100-1:1000; IHC:1:100-1:1000; WB:1:500-1:3000
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant fragment corresponding to a region within amino acids 401 and 694 of Fatty Acid Synthase (Uniprot ID#P49327)
• Formulation: 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
• Concentration: lot specific
• Purification: Purified by antigen-affinity chromatography.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 273 kDa
• Gene Name: fatty acid synthase
• Database Link:
  NP_004095
  Entrez Gene 14104 MouseEntrez Gene 50671 RatEntrez Gene 2194 Human
  UniProt ID P49327
• Background: The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha. [provided by RefSeq]
• Synonyms: FAS; OA-519; SDR27X1
• Note: Seq homology of immunogen across species: Rat (85%), Bovine (81%)

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Fatty acid biosynthesis, Insulin signaling pathway, Metabolic pathways