MVP Rabbit Polyclonal Antibody

CAT#: TA308784

Rabbit Polyclonal antibody to MVP/LRP (major vault protein)

Product Images

Sample (30 ug of whole cell lysate). A: Molt-4. 7.5% SDS PAGE. TA308784 diluted at 1:1000.

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  MVP/LRP antibody detects MVP protein by Western blot analysis. A. 30 ug Neuro2A whole cell lysate/extract. B. 30 ug GL261 whole cell lysate/extract. C. 30 ug C8D30 whole cell lysate/extract. D. 30 ug BCL-1 whole cell lysate/extract. E. 30 ug Raw264.7 whol

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  Immunohistochemical analysis of paraffin-embedded A549 xenograft, using LRP (MVP) (TA308784) antibody at 1:500 dilution.

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  MVP/LRP antibody detects MVP/LRP protein at cytosol on mouse colon by immunohistochemical analysis. Sample: Paraffin-embedded mouse colon. MVP/LRP antibody (TA308784) dilution: 1:500.

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  Immunofluorescence analysis of paraformaldehyde-fixed A431, using MVP/LRP (TA308784) antibody at 1:200 dilution.

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Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: ICC/IF:1:100-1:1000; IHC:1:100-1:1000; WB:1:500-1:3000
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant fragment corresponding to a region within amino acids 158 and 380 of MVP/LRP (Uniprot ID#Q14764)
• Formulation: 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
• Concentration: lot specific
• Purification: Purified by antigen-affinity chromatography.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 99 kDa
• Gene Name: major vault protein
• Database Link:
  NP_005106
  Entrez Gene 9961 Human
  UniProt ID Q14764
• Background: This gene encodes the major vault protein which is a lung resistance-related protein. Vaults are multi-subunit structures that may be involved in nucleo-cytoplasmic transport. This protein mediates drug resistance, perhaps via a transport process. It is widely distributed in normal tissues, and overexpressed in multidrug-resistant cancer cells. The protein overexpression is a potentially useful marker of clinical drug resistance. This gene produces two transcripts by using two alternative exon 2 sequences; however, the open reading frames are the same in both transcripts. [provided by RefSeq]
• Synonyms: LRP; VAULT1

Reference Data

• Protein Families: Druggable Genome