Caspase 14 (CASP14) Rabbit Polyclonal Antibody

CAT#: TA308792

Rabbit polyclonal antibody to Caspase 14 (caspase 14, apoptosis-related cysteine peptidase)

Product Images

Sample (30 ug of whole cell lysate). A: A431. 12% SDS PAGE. TA308792 diluted at 1:1000.

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  Immunofluorescence analysis of paraformaldehyde-fixed HeLa, using Caspase 14 (TA308792) antibody at 1:200 dilution.

Specifications

Product Data

• Applications: IF, WB
• Recommended Dilution: ICC/IF:1:100-1:1000; WB:1:500-1:3000
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a region within amino acids 171 and 242 of Caspase 14
• Formulation: 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
• Concentration: lot specific
• Purification: Purified by antigen-affinity chromatography.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 28 kDa
• Gene Name: caspase 14
• Database Link:
  NP_036246
  Entrez Gene 23581 Human
  UniProt ID P31944
• Background: This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This caspase has been shown to be processed and activated by caspase 8 and caspase 10 in vitro, and by anti-Fas agonist antibody or TNF-related apoptosis inducing ligand in vivo. The expression and processing of this caspase may be involved in keratinocyte terminal differentiation, which is important for the formation of the skin barrier. [provided by RefSeq]
• Synonyms: MGC119078; MGC119079

Reference Data

• Protein Families: Druggable Genome