ADAR1 (ADAR) Rabbit Polyclonal Antibody

CAT#: TA308833

Rabbit polyclonal antibody to Adenosine Deaminase (adenosine deaminase, RNA-specific)

Product Images

Sample (30 ug of whole cell lysate). A: 293T. 5% SDS PAGE. TA308833 diluted at 1:1000.

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  Sample (30 ug of whole cell lysate). A:NIH-3T3 5% SDS PAGE. TA308833 diluted at 1:1000.

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  Immunohistochemical analysis of paraffin-embedded Colon ca, using ADAR1 (TA308833) antibody at 1:250 dilution.

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  Immunofluorescence analysis of paraformaldehyde-fixed HeLa, using ADAR1 (TA308833) antibody at 1:200 dilution.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: ICC/IF:1:100-1:1000; IHC:1:100-1:1000; WB:1:500-1:3000
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant fragment corresponding to a region within amino acids 472 and 757 of ADAR1 (Uniprot ID#P55265)
• Formulation: 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
• Purification: Purified by antigen-affinity chromatography.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 136 kDa
• Gene Name: adenosine deaminase, RNA-specific
• Database Link:
  NP_056655
  Entrez Gene 56417 MouseEntrez Gene 81635 RatEntrez Gene 103 Human
  UniProt ID P55265
• Background: This gene encodes the enzyme responsible for RNA editing by site-specific deamination of adenosines. This enzyme destabilizes double stranded RNA through conversion of adenosine to inosine. Mutations in this gene have been associated with dyschromatosis symmetrica hereditaria. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq]
• Synonyms: ADAR1; AGS6; DRADA; DSH; DSRAD; G1P1; IFI-4; IFI4; K88DSRBP; P136
• Note: Seq homology of immunogen across species: Rat (80%)

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Cytosolic DNA-sensing pathway