FMO1 Rabbit Polyclonal Antibody

CAT#: TA308880

Rabbit polyclonal antibody to FMO1 (flavin containing monooxygenase 1)

Product Images

Sample (30 ug whole cell lysate). A:Hep G2. B:Raji. 7.5% SDS PAGE. TA308880 diluted at 1:1000

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB:1:500-1:3000
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant fragment corresponding to a region within amino acids 1 and 437 of FMO1 (Uniprot ID#Q01740)
• Formulation: 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
• Concentration: lot specific
• Purification: Purified by antigen-affinity chromatography.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 60 kDa
• Gene Name: flavin containing monooxygenase 1
• Database Link:
  NP_002012
  Entrez Gene 14261 MouseEntrez Gene 25256 RatEntrez Gene 403604 DogEntrez Gene 2326 Human
  UniProt ID Q01740
• Background: Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. [provided by RefSeq]
• Synonyms: Flavin-containing monooxygenase 1 (fetal liver); flavin containing monooxygenase 1; OTTHUMP00000033536; OTTHUMP00000033537
• Note: Seq homology of immunogen across species: Mouse (83%), Dog (88%), Pig (86%), Rat (82%), Bovine (85%)

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Drug metabolism - cytochrome P450