Inhibin beta A (INHBA) Rabbit Polyclonal Antibody

CAT#: TA308909

Rabbit Polyclonal antibody to Inhibin beta A (inhibin, beta A)

Product Images

Sample (30 ug whole cell lysate). A:H1299. B:HeLa S3. C:Hep G2. 10% SDS PAGE. TA308909 diluted at 1:1000

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  Immunohistochemical analysis of paraffin-embedded CLEAR CELL OVCA xenograft, using Inhibin beta A (TA308909) antibody at 1:500 dilution.

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  Immunofluorescence analysis of paraformaldehyde-fixed HeLa, using Inhibin beta-A (TA308909) antibody at 1:200 dilution.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: ICC/IF:1:100-1:1000; IHC:1:100-1:1000; WB:1:500-1:3000
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a region within amino acids 362 and 426 of Inhibin beta A
• Formulation: 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
• Purification: Purified by antigen-affinity chromatography.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 47 kDa
• Gene Name: inhibin beta A subunit
• Database Link:
  NP_002183
  Entrez Gene 16323 MouseEntrez Gene 29200 RatEntrez Gene 3624 Human
  UniProt ID P08476
• Background: The inhibin beta A subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumor-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta A subunit forms a homodimer, activin A, and also joins with a beta B subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion. Finally, it has been shown that the beta A subunit mRNA is identical to the erythroid differentiation factor subunit mRNA and that only one gene for this mRNA exists in the human genome. [provided by RefSeq]
• Synonyms: EDF; FRP
• Note: Seq homology of immunogen across species: Mouse (100%), Rat (100%), Cat (100%), Pig (100%), Chicken (100%), Sheep (100%), Bovine (100%)

Reference Data

• Protein Families: Druggable Genome, Secreted Protein
• Protein Pathways: Cytokine-cytokine receptor interaction, TGF-beta signaling pathway