Renin (REN) Rabbit Polyclonal Antibody

CAT#: TA308950

Rabbit Polyclonal antibody to Renin (renin)

Product Images

Renin antibody [N2C2], Internal detects REN protein by Western blot analysis. A. 30 ug K562 whole cell lysate/extract. 10 % SDS-PAGE. Renin antibody [N2C2], Internal (TA308950) dilution: 1:1000

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  Immunohistochemical analysis of paraffin-embedded OVCA xenograft, using Renin (TA308950) antibody at 1:100 dilution.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: IHC:1:100-1:1000; WB:1:500-1:3000
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant fragment corresponding to a region within amino acids 70 and 332 of Renin (Uniprot ID#P00797)
• Formulation: 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
• Concentration: lot specific
• Purification: Purified by antigen-affinity chromatography.
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 45 kDa
• Gene Name: renin
• Database Link:
  NP_000528
  Entrez Gene 5972 Human
• Background: Renin catalyzes the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone release,vasoconstriction, and increase in blood pressure. Renin, an aspartyl protease, cleaves angiotensinogen to form angiotensin I, which is converted to angiotensin II by angiotensin I converting enzyme, an important regulator of blood pressure and electrolyte balance. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause familial hyperproreninemia. [provided by RefSeq]
• Synonyms: HNFJ2
• Note: Seq homology of immunogen across species: Chimpanzee (100%)

Reference Data

• Protein Families: Druggable Genome, Secreted Protein
• Protein Pathways: Renin-angiotensin system