SMC1 (SMC1A) Rabbit Polyclonal Antibody

CAT#: TA308965

Rabbit Polyclonal antibody to SMC1A (structural maintenance of chromosomes 1A)


USD 415.00

5 Days*

Size
    • 100 ul

Product Images

Other products for "SMC1A"

Specifications

Product Data
Applications IHC, IP, WB
Recommended Dilution IHC:1:100-1:1000; WB:1:1000-1:10000
Reactivities Human
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen Recombinant fragment corresponding to a region within amino acids 1 and 248 of SMC1A (Uniprot ID#Q14683)
Formulation 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Concentration lot specific
Purification Purified by antigen-affinity chromatography.
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Predicted Protein Size 143 kDa
Gene Name structural maintenance of chromosomes 1A
Background Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1L2 or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Therefore, the encoded protein is thought to be an important part of functional kinetochores. In addition, this protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair. This gene, which belongs to the SMC gene family, is located in an area of the X-chromosome that escapes X inactivation. [provided by RefSeq]
Synonyms CDLS2; DXS423E; SB1.8; SMC1; SMC1alpha; SMC1L1; SMCB
Note Seq homology of immunogen across species: Mouse (100%), Bovine (100%)
Reference Data
Protein Families Druggable Genome
Protein Pathways Cell cycle, Oocyte meiosis

{0} Product Review(s)

0 Product Review(s) Submit review

Be the first one to submit a review

Product Citations

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.