RASSF1 Rabbit Polyclonal Antibody

CAT#: TA308998

Rabbit polyclonal antibody to RASSF1 (Ras association (RalGDS/AF-6) domain family member 1)

Product Images

Sample (30 ug whole cell lysate). A:293T. 12% SDS PAGE. TA308998diluted at 1:500

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  Immunofluorescence analysis of paraformaldehyde-fixed HeLa, using RASSF1 (TA308998) antibody at 1:100 dilution.

Specifications

Product Data

• Applications: IF, WB
• Recommended Dilution: ICC/IF:1:100-1:1000; WB:1:500-1:3000
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant fragment corresponding to a region within amino acids 50 and 344 of RASSF1 (Uniprot ID#Q9NS23)
• Formulation: 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
• Concentration: lot specific
• Purification: Purified by antigen-affinity chromatography.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 39 kDa
• Gene Name: Ras association domain family member 1
• Database Link:
  NP_733832
  Entrez Gene 56289 MouseEntrez Gene 363140 RatEntrez Gene 11186 Human
  UniProt ID Q9NS23
• Background: This gene encodes a protein similar to the RAS effector proteins. Loss or altered expression of this gene has been associated with the pathogenesis of a variety of cancers, which suggests the tumor suppressor function of this gene. The inactivation of this gene was found to be correlated with the hypermethylation of its CpG-island promoter region. The encoded protein was found to interact with DNA repair protein XPA. The protein was also shown to inhibit the accumulation of cyclin D1, and thus induce cell cycle arrest. Seven alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq]
• Synonyms: 123F2; NORE2A; RASSF1A; RDA32; REH3P21
• Note: Seq homology of immunogen across species: Mouse (91%), Rat (91%)

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Bladder cancer, Non-small cell lung cancer, Pathways in cancer