alpha Synuclein (SNCA) Mouse Monoclonal Antibody [Clone ID: 3H9]

CAT#: TA309078

Mouse Anti-alpha Synuclein Antibody

Product Images

Western blot of a rat brain lysate showing specific immunolabeling of the ~15k alpha synuclein protein

Specifications

Product Data

• Clone Name: 3H9
• Applications: WB
• Recommended Dilution: WB: 1:1,000, IF: 1:500
• Reactivities: Human, Mouse, Rat
• Host: Mouse
• Isotype: IgG
• Clonality: Monoclonal
• Immunogen: Full length human alpha synuclein expressed in E. Coli.
• Formulation: Ascites fluid + 0.01 % NaN3.
• Purification: Ascites fluid
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 15 kDa
• Gene Name: synuclein alpha
• Database Link:
  NP_000336
  Entrez Gene 20617 MouseEntrez Gene 29219 RatEntrez Gene 6622 Human
• Background: Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene. [provided by RefSeq]
• Synonyms: NACP; PARK1; PARK4; PD1

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Alzheimer's disease, Parkinson's disease