MECP2 Rabbit Polyclonal Antibody

CAT#: TA309165

Rabbit Anti-MeCP2 (Ser80) Antibody (Phospho-Specific)


USD 365.00

In Stock*

Size
    • 100 ul

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Specifications

Product Data
Applications WB
Recommended Dilution WB: 1:1,000, IHC 1:100
Reactivities Human, Mouse, Rat
Modifications Phospho-specific
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser80 conjugated to KLH
Formulation 100 µl in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.
Purification Serum
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Predicted Protein Size 75 kDa
Gene Name methyl-CpG binding protein 2
Background DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females. [provided by RefSeq]
Synonyms AUTSX3; MRX16; MRX79; MRXS13; MRXSL; PPMX; RS; RTS; RTT
Reference Data
Protein Families Druggable Genome

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