Syntaxin 1a (STX1A) Mouse Monoclonal Antibody [Clone ID: SP8]

CAT#: TA309250

Mouse Anti-Syntaxin Antibody

Product Images

Western blot of rat cortex lysate showing specific immunolabeling of the ~ 36k syntaxin 1A protein.

Specifications

Product Data

• Clone Name: SP8
• Applications: WB
• Recommended Dilution: WB: 1:1000, IHC: 1:100
• Reactivities: Hamster, Human, Porcine, Rat
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Synaptic immunoprecipitate (crude) from human brain
• Formulation: 100 µl in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.
• Purification: Protein G purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 36 kDa
• Gene Name: syntaxin 1A
• Database Link:
  NP_004594
  Entrez Gene 116470 RatEntrez Gene 6804 Human
  UniProt ID Q16623
• Background: This gene encodes a member of the syntaxin superfamily. Syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane. Syntaxins possess a single C-terminal transmembrane domain, a SNARE [Soluble NSF (N-ethylmaleimide-sensitive fusion protein)-Attachment protein REceptor] domain (known as H3), and an N-terminal regulatory domain (Habc). Syntaxins bind synaptotagmin in a calcium-dependent fashion and interact with voltage dependent calcium and potassium channels via the C-terminal H3 domain. This gene product is a key molecule in ion channel regulation and synaptic exocytosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
• Synonyms: HPC-1; P35-1; STX1; SYN1A

Reference Data

• Protein Families: Druggable Genome, Secreted Protein, Transmembrane
• Protein Pathways: SNARE interactions in vesicular transport