TDP43 (TARDBP) Rabbit Polyclonal Antibody

CAT#: TA309253

Rabbit Anti-TDP43 Antibody

Product Images

Western blot of neonatal rat brain lysate showing specific immunolabeling of the ~ 43 kDa TDP43 protein.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1:1000, IHC: 1:250
• Reactivities: Human, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to amino acid residues C-terminal to the caspase-cleavage site (between D219 and V220) of human TDP-43.
• Formulation: 100 ul in PBS + 30% glycerol
• Purification: Affinity Purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 43 kDa
• Gene Name: TAR DNA binding protein
• Database Link:
  NP_031401
  Entrez Gene 298648 RatEntrez Gene 23435 Human
  UniProt ID Q13148
• Background: HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20. [provided by RefSeq]
• Synonyms: ALS10; TDP-43

Reference Data

• Protein Families: Transcription Factors