Dux4 (DUX4L1) Mouse Monoclonal Antibody [Clone ID: P2B1]

CAT#: TA309324

Mouse Mononclonal anti-DUX4 Antibody

Product Images

Western blot using anti-DUX4 N-terminus mouse monoclonal on C2C12 cells transfected with pCS2+DUX4, which contains an additional upstream start site.

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  Immmunofluorescence staining using mouse monoclonal anti-DUX4 N-terminus on C2C12 myoblasts transfected with pCS2+DUX4. Counter-stained with DAPI for nuclei.

Specifications

Product Data

• Clone Name: P2B1
• Applications: IF, WB
• Recommended Dilution: WB, IF, IHC
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: C-terminal 76 amino acids of DUX4 with glutathione-s-transferase (gst) tag
• Formulation: TBS pH7.4, 50% glycerol
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: double homeobox 4 like 1
• Database Link:
  NP_149418
  Entrez Gene 22947 Human
• Background: This gene is located within a D4Z4 repeat array in the subtelomeric region of chromosome 4q. The D4Z4 repeat is polymorphic in length; a similar D4Z4 repeat array has been identified on chromosome 10. Each D4Z4 repeat unit has an open reading frame (named DUX4) that contains two homeoboxes; the repeat-array and ORF is conserved in other mammals. There was no evidence for transcription from standard cDNA libraries however RTPCR and in-vitro expression experiments indicate that the ORF is transcribed and the encoded protein has been reported to function as a transcriptional activator of paired-like homeodomain transcription factor 1 (PITX1; GeneID 5307). Contraction of the microsatellite repeat causes autosomal dominant facioscapulohumeral muscular dystrophy (FSHD). [provided by RefSeq]
• Synonyms: DUX10