IL2 Receptor alpha (IL2RA) Rabbit Monoclonal Antibody [Clone ID: EPR6452]

CAT#: TA310265

Rabbit Monoclonal antibody against CD25

Product Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IL2 Receptor alpha antibody [EPR6452]; TA310265, at 1/250 dilution, staining IL2 Receptor alpha in paraffin-embedded Human tonsil tissue by Immunohistochemistry.

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  Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)-Anti-IL2 Receptor alpha antibody [EPR6452] (TA310265); TA310265 showing positive staining in Hodgkin's lymphoma tissue.

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  Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)-Anti-IL2 Receptor alpha antibody [EPR6452] (TA310265); TA310265 showing negative staining in Normal liver tissue.

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  Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)-Anti-IL2 Receptor alpha antibody [EPR6452] (TA310265); TA310265 showing positive staining in Normal thymus tissue.

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  Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)-Anti-IL2 Receptor alpha antibody [EPR6452] (TA310265); TA310265 showing positive staining in Normal spleen tissue.

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Specifications

Product Data

• Clone Name: EPR6452
• Applications: IHC
• Recommended Dilution: IHC-P 1:250 - 1:500; ICC 1:100-1:250
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Monoclonal
• Immunogen: A recombinant protein fragment corresponding to human CD25 was used as an immunogen.
• Formulation: pH: 7.20
  Preservative: 0.01% Sodium azide
  Constituents: 49% PBS, 50% Glycerol, 0.05% BSA
• Purification: Tissue culture supernatant
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: interleukin 2 receptor subunit alpha
• Database Link:
  NP_000408
  Entrez Gene 16184 MouseEntrez Gene 25704 RatEntrez Gene 3559 Human
  UniProt ID P01589
• Background: CD25, or interleukin 2 (IL2) receptor alpha (IL2RA), and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (CD25) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble CD25 has been isolated and determined to result from extracellular proteolyisis. Mutations in CD25 are associated with interleukin 2 receptor alpha deficiency (1).
• Synonyms: CD25; IDDM10; IL2R; p55; TCGFR
• Note: Does not react with Mouse, Rat; Is unsuitable for IP

Reference Data

• Protein Families: Druggable Genome, ES Cell Differentiation/IPS, Transmembrane
• Protein Pathways: Cytokine-cytokine receptor interaction, Endocytosis, Hematopoietic cell lineage, Jak-STAT signaling pathway