NR5A2 Rabbit Monoclonal Antibody [Clone ID: EPR7000]

CAT#: TA310732

Rabbit Monoclonal antibody against NR5A2

Product Images

Western blot - Anti-NR5A2 / LRH1 antibody [EPR7000]; All lanes : Anti-NR5A2 / LRH1 antibody [EPR7000] at 1/1000 dilution.Lane 1 : HeLa cell lysate.Lane 2 : BxPC3 cell lysate.Lane 3 : HepG2 cell lysate.Lane 4 : MCF7 cell lysate.Lysates/proteins at 10 ug per lane.Secondary.HRP labelled goat anti rabbit at 1/2000 dilution.Predicted band size : 61 kDa.Observed band size : 65 kDa.

Specifications

Product Data

• Clone Name: EPR7000
• Applications: WB
• Recommended Dilution: WB: 1:1000 - 1:10000
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Monoclonal
• Immunogen: A synthetic peptide corresponding to residues in human NR5A2 was used as an immunogen.
• Formulation: pH: 7.20
  Preservative: 0.01% Sodium azide
  Constituents: 49% PBS, 50% Glycerol, 0.05% BSA
• Purification: Tissue culture supernatant
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 61 kDa
• Gene Name: nuclear receptor subfamily 5 group A member 2
• Database Link:
  NP_003813
  Entrez Gene 26424 MouseEntrez Gene 60349 RatEntrez Gene 2494 Human
  UniProt ID O00482
• Background: NR5A2 is a nuclear receptor originally identified in the liver and mostly known for its regulatory role in cholesterol and bile acid homeostasis. It is a key regulator of intestinal function, coordinating unanticipated actions, such as cell renewal and local immune function with important implications to common intestinal diseases, including colorectal cancer and inflammatory bowel disease. Unlike most of the other nuclear receptors, liver NR5A2 acts as a constitutively active transcription factor (1). Furthermore, NR5A2 functions in steroidogenesis in the gonad and intestine (2).
• Synonyms: B1F; B1F2; CPF; FTF; FTZ-F1; FTZ-F1beta; hB1F-2; LRH-1; LRH1
• Note: Is unsuitable for Flow Cyt,ICC,IHC-P or IP.

Reference Data

• Protein Families: Druggable Genome, Nuclear Hormone Receptor, Transcription Factors
• Protein Pathways: Maturity onset diabetes of the young