PMP70 (ABCD3) Rabbit Monoclonal Antibody [Clone ID: EPR5614]

CAT#: TA310768

Rabbit Monoclonal antibody against PMP70

Product Images

Western blot - PMP70 antibody [EPR5614]; All lanes : Anti-PMP70 antibody [EPR5614] at 1/1000 dilution.Lane 1 : 293T cell lysate.Lane 2 : SH SY5Y cell lysate.Lane 3 : Caco2 cell lysate.Lane 4 : HepG2 cell lysate.Lysates/proteins at 10 ug per lane.Predicted band size : 75 kDa.Observed band size : 70 kDa.

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  Flow Cytometry - PMP70 antibody [EPR5614]; TA310768 at 1/100 dilution staining PMP70 in permeabilized HepG2 cells by Flow cytometry (shown in red). Rabbit IgG negative control (shown in green).

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  Other-Anti-PMP70 antibody [EPR5614] (TA310768); Equilibrium disassociation constant (KD).

Specifications

Product Data

• Clone Name: EPR5614
• Applications: Assay, FC, WB
• Recommended Dilution: WB: 1:1000 - 1:10000; ICC: 1:100 - 1:250; FC: 1:100 - 1:500
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Monoclonal
• Immunogen: A synthetic peptide corresponding to residues on the C-terminus in human PMP70 was used as an immunogen.
• Formulation: PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
• Purification: Tissue culture supernatant
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 75 kDa
• Gene Name: ATP binding cassette subfamily D member 3
• Database Link:
  NP_001116146
  Entrez Gene 19299 MouseEntrez Gene 25270 RatEntrez Gene 5825 Human
  UniProt ID P28288
• Background: PMP70 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. They are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). PMP70 is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters, which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. This peroxisomal membrane protein likely plays an important role in peroxisome biogenesis. Mutations in PMP70 have been associated with some forms of Zellweger syndrome, a heterogeneous group of peroxisome assembly disorders (1).
• Synonyms: ABC43; CBAS5; PMP70; PXMP1; ZWS2
• Note: Is unsuitable for IHC-P or IP.

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: ABC transporters