SHC (SHC1) Rabbit Polyclonal Antibody

CAT#: TA312071

Rabbit polyclonal Shc (Tyr349) antibody(Phospho-specific)

Product Images

Western blot analysis of extracts from 293 cells treated with EGF (200ng/ml, 30mins), using Shc (phospho-Tyr349) antibody.The lane on the right is treated with the synthesized peptide.

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  Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using Shc (phospho-Tyr349) antibodyThe picture on the right is treated with the synthesized peptide.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 1:500~1000, IHC: 1:50~100, ELISA: 1:10000
• Reactivities: Human, Mouse, Rat
• Modifications: Phospho-specific
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: The antiserum was produced against synthesized phosphopeptide derived from human Shc around the phosphorylation site of tyrosine349 (H-Q-YP-Y-N)
• Formulation: Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: lot specific
• Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: SHC adaptor protein 1
• Database Link:
  NP_892113
  Entrez Gene 20416 MouseEntrez Gene 85385 RatEntrez Gene 6464 Human
  UniProt ID P29353
• Synonyms: SHC; SHCA
• Note: Shc (phospho-Tyr349) antibody detects endogenous levels of Shc only when phosphorylated at tyrosine349.

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Adherens junction, Arrhythmogenic right ventricular cardiomyopathy (ARVC), Chemokine signaling pathway, Chronic myeloid leukemia, Dilated cardiomyopathy, ErbB signaling pathway, Focal adhesion, Glioma, Hypertrophic cardiomyopathy (HCM), Insulin signaling pathway, Leukocyte transendothelial migration, Natural killer cell mediated cytotoxicity, Neurotrophin signaling pathway, Pathogenic Escherichia coli infection, Regulation of actin cytoskeleton, Tight junction, Vibrio cholerae infection, Viral myocarditis