PARP1 Mouse Monoclonal Antibody [Clone ID: 7A10]

CAT#: TA318859

Mouse monoclonal anti-PARP antibody, clone 7A10


USD 450.00

In Stock*

Size
    • 100 ul

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Specifications

Product Data
Clone Name 7A10
Applications FC, WB
Recommended Dilution WB: 1:500-2000, IF: 1:200-400
Reactivities Human
Host Mouse
Clonality Monoclonal
Immunogen A synthetic peptide corresponding to residues before the cleavage site of human PARP-1 was used as immunogen. The antibody only recognizes full-length form (p116) of PARP-1.
Formulation Supplied in 10 mM HEPES sodium (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol, and 0.03% sodium azide
Purification N/A
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name poly(ADP-ribose) polymerase 1
Background PARP, a 116 kDa nuclear poly (ADP-ribose) polymerase, appears to be involved in DNA repair in response to environmental stress. This protein can be cleaved by many ICE-like Caspases in vitro and is one of the main cleavage targets of caspase-3 in vivo. In human PARP, the cleavage occurs between Asp214 and Gly215, which separates the PARP amino-terminal DNA binding domain (24 kDa) from the carboxy-terminal catalytic domain (89 kDa). PARP helps cells to maintain their viability; cleavage of PARP facilitates cellular disassembly and serves as a marker of cells undergoing apoptosis.
Synonyms ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1; PARP; PARP-1; PPOL
Reference Data
Protein Families Druggable Genome, Stem cell - Pluripotency, Transcription Factors
Protein Pathways Base excision repair

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