PPP3CB Rabbit Polyclonal Antibody

CAT#: TA318865

Rabbit polyclonal anti-Calcineurin A antibody

Product Images

Western blot analysis of Calcineurin A in lysate from Jurkat cells (Lane 1) and rat kidney (Lane 2).

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1-4ug/ml, IP: 10-20ug/ml
• Reactivities: Bovine, Hamster, Human, Mouse, Rabbit, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to residues surrounding amino acids 267 of human Calcineurin A
• Formulation: 100 µg (0.2 mg/ml) affinity purified, rabbit anti-Calcineurin A polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.
• Concentration: lot specific
• Purification: Affinity purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: protein phosphatase 3 catalytic subunit beta
• Database Link:
  NP_066955
  Entrez Gene 19056 MouseEntrez Gene 24675 RatEntrez Gene 5532 Human
  UniProt ID P16298
• Background: Calcineurin is a calcium/calmodulin-dependent serine/threonine protein phosphatase. The active enzyme is a heterodimer consisting of a catalytic A subunit of 61 kDa and a myristylated regulatory B subunit of 19 kDa that binds calcium. The catalytic A subunit consists of an amino terminal catalytic domain, followed by calmodulin and B subunit binding sites, and a caboxyl-terminal autoinhibitory domain. Calnineurin is the target of immunosuppressant drugs such as cyclosporin A and FK506. Calcineurin controls the translocation of nuclear factors of activated T cells (NFAT), a family of transcriptional activators that control the expression of cytokine genes essential to immune response, from the cytosol into the nucleus of activated T cells. Calcineurin has been proposed to play an important role in mediating calcium-activated cell death.
• Synonyms: CALNA2; CALNB; CNA2; PP2Bbeta

Reference Data

• Protein Families: Druggable Genome, Phosphatase, Transcription Factors
• Protein Pathways: Alzheimer's disease, Amyotrophic lateral sclerosis (ALS), Apoptosis, Axon guidance, B cell receptor signaling pathway, Calcium signaling pathway, Long-term potentiation, MAPK signaling pathway, Natural killer cell mediated cytotoxicity, Oocyte meiosis, T cell receptor signaling pathway, VEGF signaling pathway, Wnt signaling pathway