DR6 (TNFRSF21) Rabbit Polyclonal Antibody

CAT#: TA318878

Rabbit polyclonal anti-Tnfrsf21 (DR6) antibody

Product Images

Western blot analysis of DR6 expression in lysate from Jurkat cells (Lane 1, 2), 3T3 cells (Lane 3) and rat kidney tissue lysate (Lane 4).

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 0.5-4ug/ml
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide surrounding amino acid 622 of rat DR6
• Formulation: 100 µg (0.5 mg/ml) antigen affinity purified rabbit anti-DR6 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol and 0.01% Thimerosal.
• Concentration: lot specific
• Purification: Affinity purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: tumor necrosis factor receptor superfamily member 21
• Database Link:
  NP_055267
  Entrez Gene 94185 MouseEntrez Gene 316256 RatEntrez Gene 27242 Human
  UniProt ID O75509
• Background: Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNF-R1 and Fas. Several novel death receptor including DR3, DR4, and DR5 were recently identified. A new death domain containing receptor in the TNFR family was cloned recently and termed DR6 for death receptor 6. Like TNF-R1, DR6 interacts with death domain containing adapter molecule TRADD. Overexpression of DR6 induces apoptosis and activates NF-kB and JNK. DR6 is widely expressed in human tissues and cell lines.
• Synonyms: BM-018; CD358; DR6

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Cytokine-cytokine receptor interaction