TLR3 Rabbit Polyclonal Antibody

CAT#: TA318910

Rabbit polyclonal anti-TLR3 antibody

Product Images

Western blot analysis of TLR3 expression in lysate from Jurkat cells (Lane 1 & 2) and 3T3 cells (Lane 3).

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide surrounding amino acid 805 of mouse TLR3
• Formulation: PBS, pH 7.2, containing 30% glycerol, 0.5% BSA and 0.01% thimerosal
• Concentration: lot specific
• Purification: Affinity purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: toll like receptor 3
• Database Link:
  NP_003256
  Entrez Gene 142980 MouseEntrez Gene 364594 RatEntrez Gene 7098 Human
  UniProt ID O15455
• Background: To date, at least ten members of the Toll family have been identified. TLRs recognize molecular patterns associated with microbial pathogens and induce antimicrobial immune response. TLR3 recognizes double-stranded (ds) RNA, induces the activation of NF-kB, through MyD88-dependent and -independent pathways, and the production of type I interferons (IFNs). Similar to several other members of the TLR family, TLR3 has been reported to be expressed at a very low level on the surface of human fibroblast cell lines.
• Synonyms: CD283; IIAE2

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Toll-like receptor signaling pathway