SERPINB9 Mouse Monoclonal Antibody [Clone ID: PI9-17]

CAT#: TA318921

Mouse monoclonal anti-Proteinase Inhibitor (PI-9) antibody, clone PI9-17

Product Images

Western blot analysis of recombinant PI9: Lane 1: 2 ug Lane 2: 5 ug Lane 3: 10 ug

Specifications

Product Data

• Clone Name: PI9-17
• Applications: WB
• Recommended Dilution: WB: 2-4 ug/ml, IHC: 20ug/ml
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Recombinant human full length PI9
• Formulation: 100 µg (0.5 mg/ml) mouse monoclonal antibody from culture supernatant diluted in phosphate-buffered saline (PBS) containing 50% glycerol, 1% BSA, and 0.02% thimerosal.
• Concentration: lot specific
• Purification: Affinity purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: serpin family B member 9
• Database Link:
  NP_004146
  Entrez Gene 5272 Human
  UniProt ID P50453
• Background: Proteinase inhibitor 9 (PI-9, also designated cytoplasmic antiproteinase 3, or CAP3) is a 42 kDa member of the ovalbumin family of serpins that is expressed in placenta, lung and cytotoxic lymphocytes. PI-9 is a potent inhibitor of granzyme B and of granzyme B-mediated apoptosis, and is also an inhibitor of capase-1 and, to a smaller extent, caspase-4 and caspase-8. PI-9 expression is also upregulated in response to inflammatory stimuli. This upregulation protects cells from apoptosis induced by endogenously expressed or released granzyme B, particulary during target cell killling.
• Synonyms: CAP-3; CAP3; PI-9; PI9

Reference Data

• Protein Families: Druggable Genome