JIP1 (MAPK8IP1) Rabbit Polyclonal Antibody

CAT#: TA318944

Rabbit polyclonal anti-JIP-1 antibody

Product Images

Western blot analysis of JIP-1 in Jurkat cell lysate (Lane 1), mouse intestine (Lane 2) and rat kidney (Lane 3) tissue lysates.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 0.5-4ug/ml
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide from mouse JIP1
• Formulation: 100µg (0.2mg/ml) protein A purified rabbit anti-JIP1 polyclonal antibody in phosphate-buffered saline (PBS) containing 0.5% BSA, 30% glycerol, and 0.01% thimerosal.
• Concentration: lot specific
• Purification: Affinity purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: mitogen-activated protein kinase 8 interacting protein 1
• Database Link:
  NP_005447
  Entrez Gene 19099 MouseEntrez Gene 116457 RatEntrez Gene 9479 Human
  UniProt ID Q9UQF2
• Background: JIP1 (JNK-interacting protein-1) is a cytoplasmic protein that possesses an N-terminal JNK-binding domain and a C-terminal SRC homology 3 (SH3) domain. JIP1 selectively bind to JNK, but not to the ERK or p38 MAP kinases. In addition to JNK, JIP1 binds to specific proteins of JNK pathways, including MKK7, MLK3, and DLK, all at separate binding sites. JIP1 has been identified in brain and kidney tissues, whereas JIP2a, JIP2b, and JIP3 are specifically expressed in the brain. Overexpression of JIP1 causes cytoplamic retention of JNK, thereby preventing its nuclear accumulation and the subsequent activation of the JNK pathways, indicating that JIP1 acts as a cytoplasmic anchor for JNK.
• Synonyms: IB1; JIP-1; JIP1; PRKM8IP

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: MAPK signaling pathway