Noxa (PMAIP1) Rabbit Polyclonal Antibody

CAT#: TA318945

Rabbit polyclonal anti-Noxa antibody

Product Images

Western blot analysis of Noxa expression in Jurkat cell lysate.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 0.5-4ug/ml
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide surrounding amino acid 100 of human Noxa
• Formulation: 100 µg (0.2mg/ml) protein A purified rabbit anti-Noxa polyclonal antibody in phosphate-buffered saline (PBS) containing 0.5% BSA, 30% glycerol, and 0.01% thimerosal.
• Concentration: lot specific
• Purification: Affinity purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: phorbol-12-myristate-13-acetate-induced protein 1
• Database Link:
  NP_066950
  Entrez Gene 58801 MouseEntrez Gene 492821 RatEntrez Gene 5366 Human
  UniProt ID Q13794
• Background: Noxa is a BH3-only member of the Bcl-2 family. Expression of Noxa gene involves direct activation of its promotor by p53. Increased expression of Noxa protein occurs in normal thymocytes but not in p53-deficient thymocytes. Coimmunoprecipitation data suggest that Noxa protein may interact with proteins belonging to the Bcl-2 family, such as Bcl-xL and Mcl-1. Blocking the endogenous Noxa induction results in the suppression of apoptosis. These suggest Noxa may represent a candidate mediator of p53-induced apoptosis.
• Synonyms: APR; NOXA

Reference Data

• Protein Families: Druggable Genome, Stem cell - Pluripotency
• Protein Pathways: p53 signaling pathway