MADH7 (SMAD7) Rabbit Polyclonal Antibody

CAT#: TA318948

Rabbit polyclonal anti-Smad7 antibody

Product Images

Western blot analysis of Smad7 expression in Jurkat cell lysate (Lane 1& 2) and 3T3 cell lysate (Lane 3).

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 0.5-4 ug/ml
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide from human Smad 7
• Formulation: 100 µg (0.5 mg/ml) affinity purified rabbit anti-Smad7 polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal.
• Concentration: lot specific
• Purification: Affinity purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: SMAD family member 7
• Database Link:
  NP_005895
  Entrez Gene 17131 MouseEntrez Gene 81516 RatEntrez Gene 4092 Human
  UniProt ID O15105
• Background: Smad proteins, the mammalian homologs of the Drosophila Mothers against dpp (Mad), have been implicated as downstream effectors of TGFβ/BMP signaling. Smad1, Smad5, and Smad8 are effectors of BMP2 and BMP4 function while Smad2 and Smad3 are involved in TGF-β and activin-mediated growth modulation. Smad4 has been shown to mediate all of the above activities through interaction with various Smad family members. Smad6 and Smad7 regulate the response to activin/TGFβ signaling by interfering with TGFβ-mediated phosphorylation of other Smad family members.
• Synonyms: CRCS3; MADH7; MADH8

Reference Data

• Protein Families: Druggable Genome, Transcription Factors
• Protein Pathways: TGF-beta signaling pathway