DKK2 Rabbit Polyclonal Antibody

CAT#: TA318962

Rabbit polyclonal anti-DKK2 antibody

Product Images

Western blot analysis of Dkk2 in lysate from Jurkat cells (Lane 1, 2), 3T3 cells (Lane 3) and rat kidney (Lane 4).

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 0.5-4 ug/ml
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide surrounding amino acid 241 of mouse Dkk2
• Formulation: 100 µg (0.5 mg/ml) affinity purified rabbit Dkk2 polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal.
• Concentration: lot specific
• Purification: Affinity purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: dickkopf WNT signaling pathway inhibitor 2
• Database Link:
  NP_055236
  Entrez Gene 56811 MouseEntrez Gene 295445 RatEntrez Gene 27123 Human
  UniProt ID Q9UBU2
• Background: Xenopus Dickkopf (Dkk)-1 was initially discovered as a Wnt antagonist that plays an important role in head formation. By far, four members of Dkk have been identified in mammals. Each Dkk molecule contains two conserved cysteine-rich domains. Recent studies showed that the second Cys-rich domains of Dkk1 and Dkk2 inhibited Wnt-3a-activated signaling, whereas the first Cys-rich domains had no effects. In addition, the second Cys-rich domain of Dkk-2, but not that of Dkk-1, was able to activate the canonical pathway in the presence of LRP6, and this LRP-dependent signaling does not require Dvl.
• Synonyms: DKK-2

Reference Data

• Protein Families: Adult stem cells, Cancer stem cells, Druggable Genome, ES Cell Differentiation/IPS, Secreted Protein, Stem cell relevant signaling - Wnt Signaling pathway
• Protein Pathways: Wnt signaling pathway