SHANK3 Rabbit Polyclonal Antibody

CAT#: TA319075

Rabbit polyclonal anti-SHANK3 antibody (Center)

Product Images

Western blot analysis of SHANK3 in 3T3 cell lysate with SHANK3 antibody at 1 ug/ml in (A) the absence and (B) the presence of blocking peptide.

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  Immunohistochemistry of human brain tissue with SHANK3 antibody at 2.5ug/ml.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 1ug/ml, IHC: 2.5ug/ml, ELISA
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG1
• Clonality: Polyclonal
• Immunogen: SHANK3 antibody was raised against a 19 amino acid synthetic peptide near the center of human SHANK3.
• Formulation: 100 µg (1 mg/ml) in 1X PBS containing 0.02 % sodium azide.
• Concentration: lot specific
• Purification: Affinity chromatography purified via peptide column
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: SH3 and multiple ankyrin repeat domains 3
• Database Link:
  NP_001073889
  Entrez Gene 58234 MouseEntrez Gene 85358 Human
• Background: SH3 and multiple ankyrin repeat domains 3 (SHANK3), a member of the Shank gene family, plays a role in synapse formation and dendritic spine maturation. Shank proteins (Shank 1-3) containing PDZ domains are scaffold proteins of the postsynaptic density (PSD) that connect neurotransmitter receptors and ion channels proteins to the actin cytoskeleton and G-protein-coupled signaling pathways. Transcript splice variation in the Shank family influences the spectrum of Shank-interacting proteins in the PSDs of adult and developing brain to ensure normal development. Mutations of SHANK3 are a cause of autism spectrum disorder (ASD) and the neurological symptoms of 22q13.3 deletion syndrome.
• Synonyms: DEL22q13.3; KIAA1650; PROSAP2; PSAP2; SPANK-2