IL4 Rabbit Polyclonal Antibody

CAT#: TA319287

Rabbit polyclonal IL-4 antibody Peroxidase Conjugated

Product Images

Western Blot of Rabbit Anti - IL-4 Antibody Peroxidase Conjugated Lane 1: Human IL-4 Load: 50 ng per lane Secondary antibody: IL-4 Antibody Peroxidase Conjugated at 1:1,000 for 60 min at RT Block: MB-070 for 30 min RT Predicted/Observed size: 18 kDa, 18 kDa

Specifications

Product Data

• Applications: WB
• Recommended Dilution: ELISA: 1:10,000-1:50,000, WB: 1:1,000-1:5,000, IHC: 1:500;1:2,500
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: This purified antibody was prepared from whole rabbit serum produced by repeated immunizations with full length recombinant human IL-4 protein.
• Formulation: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
• Concentration: lot specific
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: interleukin 4
• Database Link:
  NP_000580
  Entrez Gene 3565 Human
  UniProt ID P05112
• Synonyms: BCGF-1; BCGF1; BSF-1; BSF1; IL-4
• Note: IL-4 is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Reference Data

• Protein Families: Druggable Genome, Secreted Protein
• Protein Pathways: Allograft rejection, Asthma, Autoimmune thyroid disease, Cytokine-cytokine receptor interaction, Fc epsilon RI signaling pathway, Hematopoietic cell lineage, Jak-STAT signaling pathway, T cell receptor signaling pathway