P Glycoprotein (ABCB1) Rabbit Polyclonal Antibody

CAT#: TA319318

Rabbit polyclonal anti-ABCB1 antibody


USD 530.00

5 Days*

Size
    • 100 ug

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Specifications

Product Data
Applications WB
Recommended Dilution ELISA: 1:10,000 - 1:50,000, WB: 1:200 - 1:2,000, IHC: User Optimized
Reactivities Human, Monkey, Mouse, Rat, Dog
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids 262-277 of human ABCB1 protein.
Formulation 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Concentration lot specific
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name ATP binding cassette subfamily B member 1
Synonyms ABC20; CD243; CLCS; GP170; MDR1; P-GP; PGY1
Note This antibody is suitable for Cancer, Immunology and Nuclear Signaling research. ATP-Binding Cassette Sub-Family B Member 1 (ABCB1, also named P-glycoprotein) is a plasma membrane-associated multidrug transporter that utilizes the energy of ATP hydrolysis to pump toxic xenobiotics out of cells. Unique features of ABCB1 are its very broad substrate specificity and its basal ATPase activity in the absence of transport substrates. Human ABCB1 plays an important role in absorption, distribution, metabolism, excretion and toxicity of pharmacologically relevant drugs. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anti-cancer drugs. This protein also functions as a transporter across the blood-brain barrier.
Reference Data
Protein Families Druggable Genome, ES Cell Differentiation/IPS, Transmembrane
Protein Pathways ABC transporters

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.