Nrf1 Rabbit Polyclonal Antibody

CAT#: TA319375

Rabbit polyclonal anti-NRF1 antibody


USD 610.00

5 Days*

Size
    • 500 ug

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Specifications

Product Data
Applications IHC, WB
Recommended Dilution ELISA: 1:3,000 - 1:10,000, WB: 1:500 - 1:2,000, IHC: 2 mg/ml - 5 ug/ml
Reactivities Mouse
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen This protein A purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a purified recombinant mouse NRF1 protein corresponding to aa 1- 534 of the native protein.
Formulation 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Concentration lot specific
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name nuclear respiratory factor 1
Synonyms ALPHA-PAL; EWG; NRF-1; OTTHUMP00000184912
Note NRF1 (also known as nuclear respiratory factor 1, alpha palindromic binding protein and alpha-pal) is the mammalian homolog to the erect wing (ewg) Drosophila protein that is required for proper development of the central nervous system and indirect flight muscles. In mammals NRF1 functions as a transcription factor that activates the expression of the EIF2S1 (EIF2-alpha) gene. This protein links the transcriptional modulation of key metabolic genes to cellular growth and development and has been implicated in the control of nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. NRF1 forms a homodimer and binds DNA as a dimer. NRF1 shows a nuclear localization and is widely expressed in embryonic, fetal, and adult tissues. Phosphorylation of NRF1 enhances DNA binding. Multiple splice variants have been identified for this protein.
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.