TRPC6 Mouse Monoclonal Antibody [Clone ID: 3F2.H10.F2]

CAT#: TA319583

Mouse monoclonal anti-TRPC6 antibody


USD 530.00

In Stock*

Size
    • 100 ug

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Specifications

Product Data
Clone Name 3F2.H10.F2
Applications IHC, WB
Recommended Dilution ELISA: 1:10,000 - 1:50,000, WB: 1:500- 1:2,000, IHC: 2.5 ug/mL
Reactivities Chimpanzee, Human
Host Mouse
Clonality Monoclonal
Immunogen This monoclonal antibody was produced by repeated immunizations with a synthetic peptide corresponding to a region near the carboxy terminus of human TRPC6 protein.
Formulation 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Concentration lot specific
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name transient receptor potential cation channel subfamily C member 6
Synonyms FSGS2; TRP6
Note TRPC6, also known as TRP6, short transient receptor potential channel 6 and transient receptor potential cation channel subfamily C member 6, is thought to form a receptor-activated non-selective calcium permeant cation channel. TRPC6 is probably operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. It is activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C and may not to be activated by intracellular calcium store depletion. Defects in this gene are a cause of focal segmental glomerulosclerosis (FSGS). Expression of this protein has been reported in tissues such as placenta, lung, spleen, ovary, small intestine, and renal podocytes. Immunohistochemistry studies using polyclonal antibodies to this target have shown moderate to strong staining in cell types such as neurons, breast, respiratory, squamous and prostate epithelium, epidermis, placental trophoblasts, dendritic cells, and subsets of immune cells, and faint to moderate staining of adrenal, colon, ganglion cells, hepatocytes, heart, and testis.
Reference Data
Protein Families Druggable Genome, Ion Channels: Transient receptor potential, Transmembrane

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