bcl 6 (BCL6) Rabbit Polyclonal Antibody

CAT#: TA319620

Rabbit Polyclonal BCL6 Antibody

Product Images

Western blot analysis of BCL6 in rat lung tissue lysate with Bcl6 antibody at 1 ug/ml in (A) the absence and (B) the presence of blocking peptide

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: BCL6 antibody was raised against an 18 amino acid synthetic peptide near the center of human BCL6.
• Formulation: BCL6 Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: BCL6 Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 78 kDa
• Gene Name: B-cell CLL/lymphoma 6
• Database Link:
  NP_001124317
  Entrez Gene 12053 MouseEntrez Gene 303836 RatEntrez Gene 604 Human
  UniProt ID P41182
• Background: BCL6 Antibody: BCL6 was first identified as a proto-oncogene in diffuse large B cell lymphoma. BCL6, a transcriptional repressor, plays an important role in lymphomagenesis. It binds Stat recognition-like DNA elements and is required for affinity maturation of mature B cells in germinal centers and Th1/Th2 differentiation, a process that critically depends on BCL6-mediated transcriptional repression of p53. BCL6 is a pharmacological target for eradication of leukemia-initiating cells in chronic myeloid leukemia (CML).
• Synonyms: BCL5; BCL6A; LAZ3; ZBTB27; ZNF51

Reference Data

• Protein Families: Druggable Genome, Transcription Factors