p57 Kip2 (CDKN1C) Rabbit Polyclonal Antibody

CAT#: TA319629

Rabbit Polyclonal CDKN1C Antibody

Product Images

Western blot analysis of CDKN1C in 293 cell lysate with CDKN1C antibody at (A) 1 and (B) 2 ug/mL.

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  Immunofluorescence of CDKN1C in 293 cells with CDKN1C antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, IF: 20 ug/mL
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: CDKN1C antibody was raised against a 17 amino acid synthetic peptide near the amino terminus of human CDKN1C.
• Formulation: CDKN1C Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: CDKN1C Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 35 kDa
• Gene Name: cyclin-dependent kinase inhibitor 1C
• Database Link:
  NP_000067
  Entrez Gene 1028 Human
  UniProt ID P49918
• Background: CDKN1C Antibody: The cyclin-dependent kinase inhibitor 1C (CDKN1C), also known as p57KIP2, is a tight-binding, strong inhibitor of several G1 cyclin/CDK complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndrome, a cancer-predisposing syndrome, suggesting that this gene is a tumor suppressor candidate. CDKN1C is widely expressed during organogenesis with its expression declining after maturity. It is part of the CIP/KIP family of cyclin-dependent inhibitors (CKIs) which also includes CDKN1A and CDKN1B.
• Synonyms: BWCR; BWS; KIP2; p57; p57Kip2; WBS

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Cell cycle