EZH2 Rabbit Polyclonal Antibody

CAT#: TA319648

Rabbit Polyclonal EZH2 Antibody

Product Images

Western blot analysis of EZH2 in 293 cell lysate with EZH2 antibody at 1 ug/mL.

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  Immunofluorescence of EZH2 in 293 cells with EZH2 antibody at 20 ug/mL.

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  Immunocytochemistry of EZH2 in 293 cells with EZH2 antibody at 10 ug/mL.

Specifications

Product Data

• Applications: IF, WB
• Recommended Dilution: WB: 1 ug/mL, ICC: 10 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: EZH2 antibody was raised against a 17 amino acid synthetic peptide near the amino terminus of human EZH2.
• Formulation: EZH2 Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: EZH2 Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: enhancer of zeste 2 polycomb repressive complex 2 subunit
• Database Link:
  NP_001190176
  Entrez Gene 14056 MouseEntrez Gene 2146 Human
  UniProt ID Q15910
• Background: EZH2 Antibody: EZH2 was initially identified as a homolog of the drosophila Enhancer of Zeste through exon trap screening of chromosome 21. Both EZH2 and the related protein EZH1 can form complexes with the noncanonical Polycomb repressive complex-2 (PRC2) and maintain repressive chromatin, but the PRC2-EZH1 complex mediates methylation of histone H3. Both EZH1 and EZH2 are thought to function in the maintenance of embryonic stem cell pluripotency and plasticity and recently have been shown to be essential for hair follicle homeostasis and wound repair. Overexpression of EZH2 has been reported as a marker for advanced and metastatic cancers.
• Synonyms: ENX-1; ENX1; EZH1; EZH2b; KMT6; KMT6A; WVS; WVS2

Reference Data

• Protein Families: Druggable Genome, Transcription Factors