ACSL1 Rabbit Polyclonal Antibody

CAT#: TA319649

Rabbit Polyclonal ACSL1 Antibody

Product Images

Western blot analysis of ACSL1 expression in human liver tissue lysate with ACSL1 antibody at 0.25ug/ml.

• 

  Immunofluorescence of ACSL1 in human lung tissue with ACSL1 antibody at 20ug/ml.

Specifications

Product Data

• Applications: IF, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Rabbit polyclonal ACSL1 antibody was raised against an 18 amino acid peptide near the center of human ACSL1. The immunogen is located within amino acids 240 - 290 of ACSL1.
• Formulation: ACSL1 Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: ACSL1 Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 77 kDa
• Gene Name: acyl-CoA synthetase long-chain family member 1
• Database Link:
  NP_001986
  Entrez Gene 14081 MouseEntrez Gene 25288 RatEntrez Gene 2180 Human
  UniProt ID P33121
• Background: ACSL1 Antibody: Long-chain acyl coenzyme A synthetase 1 (ACSL1) catalyzes the synthesis of acyl-CoA from long-chain fatty acids in an ATP-dependent manner. ACSL1 is a member of a family of long-chain acyl-CoA synthetases which differ in substrate preference, tissue expression, and subcellular localization. In mouse, ASCL1 is the major acyl-CoA enzyme in the heart, providing 60-90% of heart ATP. Loss of ASCL1 either globally or in heart ventricles resulted in impaired fatty acid oxidation, activation of the mammalian target of rapamycin (mTOR), and cardiac hypertrophy.
• Synonyms: ACS1; FACL1; FACL2; LACS; LACS1; LACS2

Reference Data

• Protein Families: Transmembrane
• Protein Pathways: Adipocytokine signaling pathway, Fatty acid metabolism, Metabolic pathways, PPAR signaling pathway