FOXO3 Rabbit Polyclonal Antibody

CAT#: TA319652

Rabbit Polyclonal FOXO3 Antibody

Product Images

Western blot analysis of FOXO3 in A-20 cell lysate with FOXO3 antibody at (A) 0.5 and (B) 1 ug/mL.

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  Immunocytochemistry of FOXO3 in A-20 cells with FOXO3 antibody at 4 ug/mL.

Specifications

Product Data

• Applications: IF, WB
• Recommended Dilution: WB: 0.5 - 1 ug/mL, ICC:4 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: FOXO3 antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human FOXO3.
• Formulation: FOXO3 Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: FOXO3 Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: forkhead box O3
• Database Link:
  NP_001446
  Entrez Gene 56484 MouseEntrez Gene 294515 RatEntrez Gene 2309 Human
  UniProt ID O43524
• Background: FOXO3 Antibody: FOXO3 is a ubiquitously expressed 75 kDa protein member of a subfamily of the forkhead homeotic gene family of transcription factors and shuttles between the cytoplasm and nucleus. FOXO transcription factors are key players of cell fate decisions, metabolism, stress resistance, tumor suppression and are regulated by growth factors, oxidative stress or nutrient deprivation. FOXO3 is involved with mTOR in the regulation of autophagy in skeletal muscle, and activates protein degradation in atrophying muscle cells. FOXO3 has also been implicated in several neurodegenerative disorders including aging, neuromuscular disease, systemic lupus erythmatosus, stroke and diabetic complications.
• Synonyms: AF6q21; FKHRL1; FKHRL1P2; FOXO2; FOXO3A

Reference Data

• Protein Families: Druggable Genome, Transcription Factors
• Protein Pathways: Chemokine signaling pathway, Endometrial cancer, Neurotrophin signaling pathway, Non-small cell lung cancer