GRB10 Rabbit Polyclonal Antibody

CAT#: TA319657

Rabbit Polyclonal GRB10 Antibody

Product Images

Western blot analysis of GRB10 in SK-N-SH cell lysate with GRB10 antibody at (A) 1 and (B) 2 ug/mL.

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  Immunofluorescence of GRB10 in rat brain cells with GRB10 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: GRB10 antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human GRB10.
• Formulation: GRB10 Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: GRB10 Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: growth factor receptor bound protein 10
• Database Link:
  NP_005302
  Entrez Gene 14783 MouseEntrez Gene 498416 RatEntrez Gene 2887 Human
  UniProt ID Q13322
• Background: GRB10 Antibody: GRB10 belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules and function in diverse cellular processes. GRB10 is a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. Overexpression of some isoforms of GRB10 inhibits tyrosine kinase activity and results in growth suppression. GRB10 can also interact with the L isoform of the proapoptotic protein Bim. This gene is imprinted in a highly isoform- and tissue-specific manner, with expression observed from the paternal allele in the brain, and from the maternal allele in the placental trophoblasts.
• Synonyms: Grb-10; GRB-IR; IRBP; MEG1; RSS

Reference Data

• Protein Families: Druggable Genome