CD168 (HMMR) Rabbit Polyclonal Antibody

CAT#: TA319659

Rabbit Polyclonal RHAMM Antibody

Product Images

Western blot analysis of RHAMM in rat stomach tissue lysate with RHAMM antibody at 1 ug/mL.

• 

  Immunohistochemistry of RHAMM in human stomach tissue with RHAMM antibody at 2.5 ug/mL.

• 

  Immunofluorescence of RHAMM in human stomach tissue with RHAM antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 ug/mL, ICC: 2.5 ug/mL, IF: 5 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: RHAMM antibody was raised against a 18 amino acid synthetic peptide near the amino terminus of human RHAMM.
• Formulation: RHAMM Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: RHAMM Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: hyaluronan mediated motility receptor
• Database Link:
  NP_036617
  Entrez Gene 15366 MouseEntrez Gene 25460 RatEntrez Gene 3161 Human
  UniProt ID O75330
• Background: RHAMM Antibody: The hyaluronan-mediated motility receptor, also known as RHAMM, was initially identified as a soluble protein that could be released by sub-confluent migrating cells, promoting cell motility and invasion via interactions with hyaluronan (HA) and the cell surface. While RHAMM is normally poorly expressed in most normal tissues and is not required for embryonic development or normal cell homeostasis functions, its expression is increased during wound repair in response to hypoxia and fibrogenic factors. However, its overexpression is transforming in multiple types of cancers and is required for maintaining RAS transformation. RHAMM associates with BRCA1 and BARD1, attenuating the mitotic-spindle-promoting activity of RHAMM, which may contribute to tumor progression by promoting genomic instability.
• Synonyms: CD168; IHABP; RHAMM

Reference Data

• Protein Families: Druggable Genome, Stem cell - Pluripotency
• Protein Pathways: ECM-receptor interaction