PD1 (PDCD1) Mouse Monoclonal Antibody [Clone ID: 12A7D7]

CAT#: TA319693

Mouse PD-1 Monoclonal Antibody

Product Images

Western blot analysis of PD-1 in A-20 cell lysate with PD-1 antibody at 1 ug/mL.

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  Immunohistochemistry of PD-1 in mouse brain tissue with PD-1 antibody at 2.5 ug/mL.

Specifications

Product Data

• Clone Name: 12A7D7
• Applications: IHC, WB
• Recommended Dilution: WB: 1 ug/mL, ICC: 2.5 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: A ~150 amino acid recombinant protein from near the terminus terminus of mouse PD-1.
• Formulation: PD-1 Monoclonal Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: PD-1 Monoclonal Antibody is immunoaffinity chromotography purified IgG.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: programmed cell death 1
• Database Link:
  NP_005009
  Entrez Gene 18566 MouseEntrez Gene 301626 RatEntrez Gene 5133 Human
  UniProt ID Q15116
• Background: PD-1 Monoclonal Antibody: Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antig en-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PDL-1 and PDL-2. Upon binding to either of these ligands, signals generated by PD-1 inhibit the activation of the immune response in the absence of "danger signals" such as LPS or other molecules associated with bacteria or other pathogens. Evidence for this is seen in PD1-null mice who exhibit hyperactivated immune systems and autoimmune diseases. Despite its predicted molecular weight, PD-1 often migrates at higher molecular weight in SDS-PAGE.
• Synonyms: CD279; hPD-1; hPD-l; hSLE1; PD-1; PD1; SLEB2

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Cell adhesion molecules (CAMs), T cell receptor signaling pathway