PD1 (PDCD1) Mouse Monoclonal Antibody [Clone ID: 12A7D7]

CAT#: TA319693

Mouse PD-1 Monoclonal Antibody


USD 430.00

5 Days*

Size
    • 100 ug

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Specifications

Product Data
Clone Name 12A7D7
Applications IHC, WB
Recommended Dilution WB: 1 ug/mL, ICC: 2.5 ug/mL
Reactivities Human, Mouse, Rat
Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen A ~150 amino acid recombinant protein from near the terminus terminus of mouse PD-1.
Formulation PD-1 Monoclonal Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration 1ug/ul
Purification PD-1 Monoclonal Antibody is immunoaffinity chromotography purified IgG.
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name programmed cell death 1
Background PD-1 Monoclonal Antibody: Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antig en-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PDL-1 and PDL-2. Upon binding to either of these ligands, signals generated by PD-1 inhibit the activation of the immune response in the absence of "danger signals" such as LPS or other molecules associated with bacteria or other pathogens. Evidence for this is seen in PD1-null mice who exhibit hyperactivated immune systems and autoimmune diseases. Despite its predicted molecular weight, PD-1 often migrates at higher molecular weight in SDS-PAGE.
Synonyms CD279; hPD-1; hPD-l; hSLE1; PD-1; PD1; SLEB2
Reference Data
Protein Families Druggable Genome, Transmembrane
Protein Pathways Cell adhesion molecules (CAMs), T cell receptor signaling pathway

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.